The comparisons between participants included in the current analysis and those excluded were evaluated by the Student’s t test for normally distributed variables, the Wilcoxon rank-sum test for skewed variables, and the chi-squared test for categorical variables. The associations between baseline PFASs and changes in body weight and RMR during the period of weight loss (first 6 months) or weight regain (6–24 months) were examined using linear regression. The least-square means of changes in body weight (at 6, 12, 18, and 24 months) and RMR (at 6 and 24 months) according to tertiles of baseline PFAS concentrations were calculated. In addition, the relationship between PFASs and other potential mediators including thyroid hormones and leptin were further evaluated using linear regression. Covariates considered in multivariate adjustments included baseline age (continuous), sex, race, educational attainment (high school or less, some college, or college graduate or beyond), smoking status (never, former, or current smoker), alcohol consumption (continuous), physical activity (continuous), the 4 diet groups, and baseline BMI (or baseline RMR for the analysis of RMR change). Moreover, menopausal status and hormone replacement therapy (women only) were also entered into the model in a sensitivity analysis. To test the linear trend of the associations of baseline PFAS concentrations with changes in body weight and RMR, we assigned a median value to each tertile of PFAS concentration and treated it as a continuous variable. We also tested the linear trend using the PFAS concentrations as continuous variables (log10-transformed). In an exploratory analysis, factor analysis was used to explore the potential exposure patterns of PFASs.
There's a reason you've been hearing so much about cutting meat out of your diet lately. It's not just great for your body, but also a quick way to shed some extra pounds. "Consider swapping a few meat-centric meals each week for ones centered around vegetarian proteins — or give a full-fledged vegetarian diet a try if that's of interest to you," Gorin says. "Research shows eating a vegetarian diet may boost and speed up weight loss, resulting in a loss of up to 10 pounds." Gorin recommends topping a salad or filling a veggie taco with vegetarian protein sources like pulses — which are beans, chickpeas, lentils, and dried peas — to give your weight loss a boost. One study found eating ¾ cup of pulses daily led to a loss of close to a pound over about six weeks, versus people not eating pulses daily.
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Izzy says: "If you are struggling to prepare meals that fit into your calorie allowance, most nutritionists are in agreement that portion controlled, calorie counted meals are an effective and convenient solution. You can find a number of options in your supermarket, or a delivered diet service like Diet Chef can do all the hard work for you – allowing you to still tuck into curries and pasta, whilst adding your own fruit and vegetables on the side."
To prep his patients for success, Dr. Seltzer tells them to plan around a large evening meal by eating a lighter breakfast and lunch—NBD since most people who eat a meal before bed tend to wake up feeling relatively full, he says. Research suggests balanced bedtime meals may also promote steady next-day blood sugar levels, which also helps with appetite regulation.
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I'm already seeing a lot of success here. I’ve lost over 50 pounds, which is a significant amount for three months, but I feel good about it as we're both monitored physically and mentally, and I know I'm doing it in a healthy way. But I don't really care about the number on the scale. For me it's all about the non-scale victories. For instance, I used to be uncomfortable with anything fitness related but now I enjoy trying new workouts. I can ride a bike, lift weights, and many other things I couldn't do as easily before.
PFASs are extensively used in many industrial and consumer products, including food packaging, paper and textile coatings, and non-stick cookware [31–34]. A recent study reported that the drinking water supplies for at least 6 million US citizens may exceed the US Environmental Protection Agency’s health advisory limit for lifetime exposure to PFOS and PFOA from drinking water . In addition, these compounds are extremely stable in the environment and have a long elimination half-life in the human body , thus rendering PFASs a possible threat to human health. Due to the potential metabolic abnormalities associated with elevated PFAS levels, we aimed to examine the associations of PFAS exposure with changes in body weight and RMR in the well-designed and rigorously conducted POUNDS (Preventing Overweight Using Novel Dietary Strategies) Lost trial .